Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells
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چکیده
منابع مشابه
Manganese Superoxide Dismutase (MnSOD)
2 Introduction 3 Phylogenetic distribution and subcellular localization 3 Kinetics and mechanism 3 Molecular and chemical structure 5 Biological significance 8 Summary 9 References 10 Abstract Manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme that protects cells from oxidative stress by catalyzing dismutation of superoxide (O2 ) to hydrogen peroxide and oxygen in the mito...
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In vitro synthesis of Escherichia coli manganese-containing superoxide dismutase, directed by the plasmid pDT1-5, has been achieved. The Mn superoxide dismutase polypeptide was identified by electrophoresis on polyacrylamide gels, immunoprecipitation, and the competitive immunoprecipitation effect of pure, active E. coli Mn superoxide dismutase. Dithiothreitol and glutathione, but not cysteine,...
متن کاملCopper- and zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors.
Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copper- and zinc-containing superoxide dismutase (CuZn superoxide dismutase) and manganese-containing superoxide dismutase (Mn superoxide dismutase) were specifically assayed in human malignant tumors and for comparison in human tissues. The tumors possessed les...
متن کاملCopper- and Zinc-containing Superoxide Dismutase and Manganese- containing Superoxide Dismutase in Human Tissues and Human Malignant Tumors1
Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...
متن کاملTissues and Human Malignant Tumors Manganese-containing Superoxide Dismutase in Human Copper- and Zinc-containing Superoxide Dismutase and Updated Version
Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2009
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2009.04.018